Isaac married Carrie H. Nalley on 14 Jul 1920 in Ohio, USA. Carrie (daughter of Albert Maywood Nalley and Minnie Maude McVay) was born on 3 Nov 1899 in Sycamore Valley, Monroe County, Ohio, USA; died on 14 Aug 1984 in Marietta, Washington County, Ohio, USA; was buried in Creighton Ridge Church of Christ Cemetery, Marr, Bethel Township, Monroe County, Ohio, USA. [Group Sheet] [Family Chart]

1. Dorothia Ayers was born on 24 Aug 1918 in Monroe County, Ohio, USA; died on 30 Nov 2010 in Monroe County Care Center, Woodsfield, Monroe County, Ohio, USA; was buried in Pleasant Ridge Church of Christ Cemetery, Washington Township, Monroe County, Ohio, USA.
2. Harold L. Ayers was born on 26 Dec 1920; died on 12 Aug 1983.
3. Pearl Irene Ayers was born on 22 Oct 1922 in Monroe County, Ohio, USA; died on 26 Jul 1994 in Massillon, Stark County, Ohio, USA; was buried in Creighton Ridge Church of Christ Cemetery, Marr, Bethel Township, Monroe County, Ohio, USA.
4. Charles Melvin Ayers was born on 8 Aug 1926 in Sycamore Valley, Monroe County, Ohio, USA; died on 14 Jul 2013 in Lewisville, Monroe County, Ohio, USA; was buried on 17 Jul 2013 in Pleasant Ridge Church of Christ Cemetery, Washington Township, Monroe County, Ohio, USA.
5. Carl Emerson Ayers was born on 12 Aug 1931 in Monroe County, Ohio, USA; died on 26 Jan 2004 in Wetzel County Hospital, New Martinsville, Wetzel County, West Virginia, USA; was buried in Pleasant Ridge Church of Christ Cemetery, Washington Township, Monroe County, Ohio, USA.